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A practical CTO security checklist to be Mythos-ready

Written by
Dania Durnas

Earlier this year, a lone hacker and a commercial AI subscription took down the Mexican government, stealing a massive trove of sensitive data in an attack that would previously have taken a skilled team months. And that was with a publicly available Claude model.

Anthropic's Mythos has since found thousands of zero-day vulnerabilities across every major operating system and browser, including flaws that survived decades of human review and millions of automated security tests. The window between vulnerability and working exploit is now hours, and the skill required to pull off a serious attack keeps dropping.

But defenders have the context attackers don't. You have your source code, your runtime behavior, your architecture, and your dependency graph. The organizations that will be ready are the one that are proactive rather than waiting for a scan to tell them something is wrong. This checklist is built around the defenders' advantages: know what you run, control your supply chain, find real issues before they surface elsewhere, and fix them faster than the exploit cycle.

For the teams that want to prepare for Mythos, this is for you.

A practical checklist for CTOs navigating new threats from Mythos and related models

In this new Mythos-Ready checklist, each item is written for the person who has to actually act on it, with enough context to understand why it matters now. While it's framed for CTOs, the items touch enough ground that security leads and engineering managers will find it directly relevant to the areas they own.

This is a living reference, so you can return to it when your stack changes or when a new model ships that changes what attackers can do. The threats are moving fast enough that what was low priority six months ago may be urgent today.

The checklist is also built on the premise that defenders can win. The items here are about making sure you're actually using your advantages before someone else finds the issues first.

We've pulled out a few items below to give you a sense of what's inside.

Treat patching as a continuous pipeline

AI tools in malicious hands can reverse-engineer a vendor patch, figure out what it fixes, and produce a working exploit in hours. Your release process needs to ship security fixes the same day they're available. Measure how long it actually takes your team to go from "critical patch available" to "running in production" and drive that number down.

Scope AI agent permissions

Coding agents and MCP servers need the same access controls you'd apply to any production user. Define what they can read, write, execute, and reach. An agent with extensive permissions and no logging is an unmonitored insider with a direct line to your codebase.

Secure your agentic supply chain

A compromised MCP server can bend agent behavior in ways that are difficult to spot and even harder to trace back. Vet every agentic component before connecting it to your systems, the same way you'd evaluate any third-party dependency.

Establish a security review gate for AI-generated code

AI coding tools produce code faster than review processes were built to handle. Put a review gate in place before AI-generated code reaches production, and make sure it covers generated tests, infra config, and dependency changes, not just application code.

Fix-path readiness

For critical vulnerabilities, decide in advance who owns the fix, who signs off, and how it gets to production outside your normal release cycle. Teams need to ship the fix faster than an outside AI attacker can find it.

Download the Mythos-ready security checklist

Those are just a few of the items covered. The full checklist walks through attack surface inventory, agentic supply chain controls, AI-generated code review, dependency and malware checks, incident response for AI-speed attacks, and more.

Download the Mythos-Ready Security Checklist now and start building the practices that hold up regardless of what model an attacker is running.

Download the full checklist

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